The Compability Level of Tuberculin Skin Test and T-SPOT.TB, Sensitivity and Spesifisity of T-SPOT.TB in Detecting Latent Tuberculosis in Hemodialysis Patients

Background: Controling Latent Tuberculosis Infection (LTBI) is important for the End TB Strategy program. The prevalence of LTBI and reactivation to active tuberculosis are increased in immunodeficiency conditions, such on hemodialialysis patients. Laten can be diagnosted by Tuberculin Skin Test (TST) immunoglobulin release assay (IGRA). This diagnostic study aimed determine agreement level TST T-SPOT.TB, accurancy correlation between T cluster differentiation 4 (CD4+) cell counts with T-SPOT.TB. Methods: a cross sectional design was performed hemodialysis patients Dr. Moewardi Surakarta Hospital May 2018. subject had T-SPOT.TB examinations using 2 Tuberkulin Unit (TU) intradermal purified protein derivate (PPD) RT 23 (Biofarma, Bandung) venous blood ELISPOT analysis, respectively. Statistical analysis used windows SPSS 21. Results: There were 30 subjects. 23.3%. substantial (K=0.667;P<0.001). sensitivity specificity 66.7% 95.8%, no significant CD4+ (R=0,253;P=0,177), ESAT-6SFUs (R=-0.169;P=0.317), CFP-10 SFUs (R=0.006;P=0.975), highest value ESAT-6/CFP-10 SFUs, (R=-0.070;P=0.741). Conclusion: high patients, thus early detection necessary. examination recommended tool because its practical use, inexpensive, does not require skilled personnel.